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줄기세포 | 2022-02-01 CD26 Inhibition Potentiates the Therapeutic Effects of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells by Delaying Cellular Senescence
제대혈 줄기세포 내 CD26 억제는 세포노화를 지연시켜 치료효과를 강화 시킴.· 발행정보 | Front Cell Dev Biol. 2021; 9: 803645. Published online 2022 Feb 1. doi: 10.3389/fcell.2021.803645 · 저자 | Miyeon Kim, Jinyoung Go, Ji Hye Kwon, Hye Jin Jin, Yun Kyung Bae, Eun-Young Kim, Eun-Ju Chang, Soo Jin Choi and Seong Who Kim |
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줄기세포 | 2021-09-14 Intracerebroventricular injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer’s disease dementia: a phase I clinical trial
임상 1상 시험에서, 경·중등도 알츠하이머 치매 환자의 뇌실 내에 Ommaya reservoir를 통한 hUCB-MSCs 반복투여는 타당하고 안전함을 확인함.· 발행정보 | Alzheimers Res Ther. 2021; 13: 154. doi: 10.1186/s13195-021-00897-2 · 저자 | Hee Jin Kim, Kyung Rae Cho, Hyemin Jang, Na Kyung Lee, Young Hee Jung, Jun Pyo Kim, Jung Il Lee, Jong Wook Chang, Seongbeom Park, Sung Tae Kim, Seung Whan Moon, Sang Won Seo, Soo Jin Choi, and Duk L. Na |
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SMUP-Cell | 2021-09-14 PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model
주입형 SMUP-Cell 치료제에서 분비한 PTX-3의 관절염 통증 감소 효능· 발행정보 | Cells. 2021 Sep 14;10(9):2420. doi: 10.3390/cells10092420. · 저자 | Minju Lee, Gee-Hye Kim, Miyeon Kim, Ji Min Seo, Yu Mi Kim, Mi Ra Seon, Soyoun Um, Soo Jin Choi, Wonil Oh, Bo Ram Song, Hye Jin Jin |
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뉴모스템 | 2021-04-20 Stem cells for bronchopulmonary dysplasia in preterm infants: A randomized controlled phase II trial
임상 2상 시험에서, 뉴모스템의 기관내 이식은 안전하고 타당하며, 임신 23~24주 하위그룹 조산아에서 중증 기관지폐이형성증의 2차평가지표를 유의하게 개선함. 따라서 현재 임신 23~24주의 조산아에 초점을 맞춘 대규모 통제된 추가 임상 2상 시험을 수행중임.· 발행정보 | Stem Cells Transl Med. 2021 Aug;10(8):1129-1137. doi: 10.1002/sctm.20-0330. · 저자 | So Yoon Ahn, Yun Sil Chang, Myung Hee Lee, Se In Sung, Byong Sop Lee, Ki Soo Kim, Ai-Rhan Kim, Won Soon Park |
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줄기세포 | 2021-04-15 Positively correlated CD47 activation and autophagy in umbilical cord blood-derived mesenchymal stem cells during senescence
제대혈 줄기세포 내 CD47이 노화 및 자가포식 활동에 미치는 영향.· 발행정보 | Stem Cells Int. 2021 Apr 15;2021:5582792. doi: 10.1155/2021/5582792. · 저자 | Gee-Hye Kim, Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um and Hye Jin Jin |
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카티스템 | 2021-02-20 Allogenic Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Are More Effective Than Bone Marrow Aspiration Concentrate for Cartilage Regeneration After High Tibial Osteotomy in Medial Unicompartmental Osteoarthritis of Knee
무릎 슬관절 내측 골관절염 환자에서 BMAC 대비 카티스템 투여가 연골재생에 더 효과적임.· 발행정보 | Arthroscopy. 2021 Aug;37(8):2521-2530. doi: 10.1016/j.arthro.2021.02.022. · 저자 | Nam-Hun Lee, Seung-Min Na, Hyeon-Wook Ahn, Joon-Kyoo Kang, Jong-Keun Seon, Eun-Kyoo Song |
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카티스템 | 2021-01-25 Allogenic umbilical cord blood-derived mesenchymal stromal cell implantation was superior to bone marrow aspirate concentrate augmentation for cartilage regeneration despite similar clinical outcomes
HTO를 시행한 무릎 골관절염 환자에서 BMAC 대비 카티스템 투여가 연골재생에 더 효과적임.· 발행정보 | Knee Surg Sports Traumatol Arthrosc. 2022 Jan;30(1):208-218. doi: 10.1007/s00167-021-06450-w. · 저자 | Hong‑Yeol Yang, Eun‑Kyoo Song, Sung‑Ju Kang, Woo‑Kyoung Kwak, Joon‑Kyoo Kang, Jong‑Keun Seon |
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제대혈 | 2021-01-14 High Integrity and Fidelity of Long-Term Cryopreserved Umbilical Cord Blood for Transplantation
장기간 보관된 냉동제대혈의 안정적인 생존율 회복과 높은 기능적 우수성에 관한 연구· 발행정보 | J Clin Med. 2021 Jan 14;10(2):293. doi: 10.3390/jcm10020293. · 저자 | Gee-Hye Kim, Jihye Kwak, Sung Hee Kim, Hee Jung Kim, Hye Kyung Hong, Hye Jin Jin, Soo Jin Choi, Wonil Oh, Soyoun Um |
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카티스템 | 2021-01-12 Allogeneic Umbilical Cord Blood-Derived Mesenchymal Stem Cell Implantation Versus Microfracture for Large, Full-Thickness Cartilage Defects in Older Patients: A Multicenter Randomized Clinical Trial and Extended 5-Year Clinical Follow-up
카티스템 임상 3상 시험에서, 카티스템 투여는 골관절염 유무에 관계없이 연골 결손이 있는 환자에서 미세골절에 비해 최대 5년까지 통증 및 기능의 더 지속적인 개선 효능을 나타냄.· 발행정보 | Orthop J Sports Med. 2021 Jan 12;9(1):2325967120973052. doi: 10.1177/2325967120973052. · 저자 | Hong-Chul Lim, Yong-Beom Park, Chul-Won Ha, Brian J Cole, Beom-Koo Lee, Hwa-Jae Jeong, Myung-Ku Kim, Seong-Il Bin, Chong-Hyuk Choi, Choong Hyeok Choi, Jae-Doo Yoo, Cartistem Research Group; Jung-Ro Yoon, Jun-Young Chung |
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SMUP-Cell | 2021-01-03 Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.
작은 사이즈의 제대혈 유래 줄기세포이 SASP 활성화와 연관된 TLR2 및 TLR5 신호전달을 억제시켜, 세포노화를 지연시킴.· 발행정보 | Cells. 2021 Jan 3;10(1):63. doi: 10.3390/cells10010063. · 저자 | Ji Hye Kwon, Miyeon Kim, Soyoun Um, Hyang Ju Lee, Yun Kyung Bae, Soo Jin Choi, Hyun Ho Hwang, Wonil Oh, Hye Jin Jin |